Resveratrol and 1,25-dihydroxyvitamin D decrease Lingo-1 levels, and improve behavior in harmaline-induced Essential tremor, suggesting potential therapeutic benefits

Abstract Essential tremor (ET) is a neurological disease that impairs motor and cognitive functioning. A variant of the Lingo-1 genetic locus is associated with a heightened ET risk, and increased expression of cerebellar Lingo-1. Lingo-1 has been associated with neurodegenerative processes; however...

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Bibliographic Details
Published in:Scientific Reports
Main Authors: Zeynab Pirmoradi, Mohsen Nakhaie, Hoda Ranjbar, Davood Kalantar-Neyestanaki, Kristi A. Kohlmeier, Majid Asadi-Shekaari, Amin Hassanshahi, Mohammad Shabani
Format: Article
Language:English
Published: Nature Portfolio 2024-04-01
Subjects:
Essential tremor
Resveratrol
1,25-Dihydroxyvitamin D
Harmaline
Sirt1
Online Access:https://doi.org/10.1038/s41598-024-60518-4

Internet

https://doi.org/10.1038/s41598-024-60518-4

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