Synthesis, biological evaluation and in silico study of 4-(benzo[d]thiazole-2-yl) phenols based on 4-hydroxy coumarin as acetylcholinesterase inhibitors

Abstract Alzheimer’s disease, characterized by cognitive decline and memory loss, is associated with decreased acetylcholine levels due to acetylcholinesterase (AChE) activity. Compounds containing a coumarin heterocyclic core coupled with thiazole exhibit excellent acetylcholinesterase inhibitory a...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Bi Bi Fatemeh Mirjalili, Seyedeh Azita Fazeli Attar, Fereshteh Shiri
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-11-01
Subjects:	Coumarine heterocyclic Acetylcholinesterase inhibitors Alzheimer’s disease Molecular docking Molecular dynamic
Online Access:	https://doi.org/10.1038/s41598-024-74001-7