Synthesis, cytotoxicity study of novel bisacridine derivatives and their interaction with c-myc promoter G-quadruplex/i-motif

Objective: To synthesize novel bisacridine derivatives A1-A4 and study cytotoxicity and their interaction with c-myc G-quadruplex/i-motif DNA. Method: Bisacridines A1-A4 were synthesized according to the conventional reaction method. Fluorescence resonance energy transfer (FRET) melting assay, Surfa...

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Bibliographic Details

Published in:	Journal of Holistic Integrative Pharmacy
Main Authors:	Bing Shu, Wang-liang Chen, Jia-lin Song, Shen Fang, Jiong-bang Li, Shang-shi Zhang
Format:	Article
Language:	English
Published:	KeAi Communications Co., Ltd. 2023-12-01
Subjects:	Synthesis Bisacridine derivatives G-quadruplex I-motif Cytotoxicity
Online Access:	http://www.sciencedirect.com/science/article/pii/S2707368824000037