Herpes simplex virus 1 glycoprotein C promotes virus penetration from endosomes during entry, independent of interaction with heparan sulfate

Herpes simplex virus 1 (HSV-1) gC is a multi-functional glycoprotein present in the viral envelope and on the surface of infected cells. Virion gC, and to a lesser extent the fusion protein gB, interacts with host heparan sulfate to mediate HSV-1 attachment to the cell surface. Virion gC selectively...

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Bibliographic Details

Published in:	Frontiers in Microbiology
Main Authors:	Seth M. Schneider, Giulia Tebaldi, Katrina A. Gianopulos, Darin J. Weed, Suzanne M. Pritchard, Chloe Leach, Anthony V. Nicola
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-04-01
Subjects:	herpes simplex virus fusion glycoprotein C heparan sulfate virus entry virus penetration
Online Access:	https://www.frontiersin.org/articles/10.3389/fmicb.2025.1549349/full