Protective Effects of Interleukin‐1 Inhibition With Anakinra in Mouse Models of Ischemic Stroke With and Without Reperfusion

Background Severe brain ischemia is associated with life‐threatening edema and inflammation. Interleukin‐1 is a crucial mediator of inflammation, and its blockade showed benefits in experimental stroke. We studied anakinra, a modified recombinant human interleukin‐1 receptor antagonist, in mouse mod...

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الحاوية / القاعدة:	Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
المؤلفون الرئيسيون:	Nerea Chaparro‐Cabanillas, Alicia Aliena‐Valero, Jordi Pedragosa, Leire Pedrosa, Milagros Honores, Mercè Rossinyol‐Boladeres, Juan B. Salom, Ángel Chamorro, Juan I. Arostegui, Xabier Urra, Carles Justicia, Anna M. Planas
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	Wiley 2025-05-01
الموضوعات:	anakinra cytokines edema inflammation ischemic stroke malignant infarction
الوصول للمادة أونلاين:	https://www.ahajournals.org/doi/10.1161/JAHA.124.040474