A PREDICTIVE TOXICITY STUDY OF PEIs, PAMAM AND ZAC DENDRIMERS

Polyethyleneimines (PEIs) and polyamidoamine dendrimers (PAMAM) are widely used as non-biological transporters in modern gene therapies. In this study, several zero-generation aromatic core “ZAC” dendrimers were computationally studied for predictive toxicity assessment. The chemical synthesis of t...

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Bibliographic Details
Published in:Studia Universitatis Babes-Bolyai Chemia
Main Authors: Claudiu N. LUNGU, Csaba PAIZS, Melinda Emese FÜSTÖS (LÁSZLÓ), Anamaria ORZA, Mircea V. DIUDEA, Ireneusz P. GRUDZINSKI
Format: Article
Language:English
Published: Babes-Bolyai University 2019-06-01
Subjects:
molecular descriptors, pharmacophore, QSAR, continuous structures, toxicity, maximum recommended daily dose, dendrimers
Online Access:https://studia.reviste.ubbcluj.ro/index.php/chemia/article/view/8030

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https://studia.reviste.ubbcluj.ro/index.php/chemia/article/view/8030

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