Unsupervised Clustering of Optical Coherence Tomography Data in Patients with Leber Hereditary Optic Neuropathy using Non-Negative Matrix Factorization and K-Means: A Comparison

INTRODUCTION Leber Hereditary Optic Neuropathy (LHON) is a rare genetic neurodegenerative disorder of the optic nerve, caused by mitochondrial DNA (mtDNA) pathogenic variants. It leads to sudden and severe central vision loss, mostly bilateral, typically in young adult males (onset age 18–35), t...

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Bibliographic Details

Published in:	Epidemiology, Biostatistics and Public Health
Main Authors:	Martina Romagnoli, Michele Carbonelli, Giulia Amore, Victoria Lee Caporali, Claudio Fiorini, Piero Barboni, Annarita Vestri, Luigi Palla, Valerio Carelli, Chiara La Morgia
Format:	Article
Language:	English
Published:	Milano University Press 2025-09-01
Online Access:	https://riviste.unimi.it/index.php/ebph/article/view/29503