Generative and integrative modeling for transcriptomics with formalin fixed paraffin embedded material

Abstract Background Formalin-fixed paraffin embedded (FFPE) samples suffer from the degradation of nucleic acids, a problem that becomes particularly acute with samples stored for extended periods. It remains challenging to profile FFPE using high-throughput sequencing technologies including RNA-seq...

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Bibliographic Details
Published in:Journal of Translational Medicine
Main Authors: Eliseos J. Mucaki, Wenhan Zhang, Aryamaan Saha, Sabina Trebinjac, Sharon Nofech-Mozes, Eileen Rakovitch, Vanessa Dumeaux, Michael T. Hallett
Format: Article
Language:English
Published: BMC 2025-09-01
Subjects:
Formalin fixed paraffin embedded
RNA-sequencing
Generative modeling
Graph attention networks
Online Access:https://doi.org/10.1186/s12967-025-07031-y

Internet

https://doi.org/10.1186/s12967-025-07031-y

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