Impact of rheumatoid factors on the function of therapeutic monoclonals specific for PD-1/PD-L1

Abstract The efficacy of blocking antibodies against programmed death-1 (PD-1) and its ligand (PD-L1) is modulated by signalling through their Fc regions. The Fc region of anti-PD-1/PD-L1 antibodies, when cell-bound, represents a potential target for recognition by circulating rheumatoid factor (RF)...

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發表在:	Cancer Immunology, Immunotherapy
Main Authors:	Barry D. Hock, Liping Goddard, Lachlan J. Dobson, Sean A. MacPherson, John L. O’Donnell, Judith L. McKenzie, Alexander D. McLellan
格式:	Article
語言:	英语
出版:	Springer 2025-05-01
主題:	Rheumatoid factor PD-1 PD-L1 Antibody Fc receptor
在線閱讀:	https://doi.org/10.1007/s00262-025-04078-0