24-Hydroxycholesterol Induces Tau Proteasome-Dependent Degradation via the SIRT1/PGC1α/Nrf2 Pathway: A Potential Mechanism to Counteract Alzheimer’s Disease

Considerable evidence indicates that cholesterol oxidation products, named oxysterols, play a key role in several events involved in Alzheimer’s disease (AD) pathogenesis. Although the majority of oxysterols causes neuron dysfunction and degeneration, 24-hydroxycholesterol (24-OHC) has recently been...

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Bibliographic Details
Published in:Antioxidants
Main Authors: Gabriella Testa, Serena Giannelli, Barbara Sottero, Erica Staurenghi, Giorgio Giaccone, Paola Caroppo, Paola Gamba, Gabriella Leonarduzzi
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Subjects:
24-hydroxycholesterol
sirtuin 1
Nrf2
tau
Alzheimer’s disease
proteasome
Online Access:https://www.mdpi.com/2076-3921/12/3/631

Internet

https://www.mdpi.com/2076-3921/12/3/631

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