Optimizing the use of in vitro transcribed SGK1-mRNA as a therapeutic tool to treat female infertility

Abstract Objectives Gene therapy has emerged as an encouraging therapeutic approach for several diseases. The use of plasmid DNA (pDNA) or viral vectors encoding proteins have yielded low efficacy in recent trials. Synthetic messenger RNA (mRNA), also known as in vitro transcribed mRNA (IVT-mRNA), i...

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Bibliographic Details

Published in:	BMC Research Notes
Main Authors:	Itishri Sahu, Fabienne Engelmann, Brian Weidensee, Harivignesh Ganesan, Sara Y. Brucker, Yogesh Singh, Madhuri S. Salker
Format:	Article
Language:	English
Published:	BMC 2025-07-01
Subjects:	IVT-mRNA SGK1 Fertility
Online Access:	https://doi.org/10.1186/s13104-025-07346-5