Single-Cell Hypertrophy Promotes Contractile Function of Cultured Human Airway Smooth Muscle Cells via Piezo1 and YAP Auto-Regulation

Severe asthma is characterized by increased cell volume (hypertrophy) and enhanced contractile function (hyperresponsiveness) of the airway smooth muscle cells (ASMCs). The causative relationship and underlying regulatory mechanisms between them, however, have remained unclear. Here, we manipulated...

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Bibliographic Details
Published in:Cells
Main Authors: Kai Ni, Bo Che, Rong Gu, Chunhong Wang, Yan Pan, Jingjing Li, Lei Liu, Mingzhi Luo, Linhong Deng
Format: Article
Language:English
Published: MDPI AG 2024-10-01
Subjects:
ASMC hypertrophy
contractile function
cell volume
membrane tension
Piezo1
YAP
Online Access:https://www.mdpi.com/2073-4409/13/20/1697

Internet

https://www.mdpi.com/2073-4409/13/20/1697

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