Single-Cell Hypertrophy Promotes Contractile Function of Cultured Human Airway Smooth Muscle Cells via Piezo1 and YAP Auto-Regulation

Severe asthma is characterized by increased cell volume (hypertrophy) and enhanced contractile function (hyperresponsiveness) of the airway smooth muscle cells (ASMCs). The causative relationship and underlying regulatory mechanisms between them, however, have remained unclear. Here, we manipulated...

وصف كامل

التفاصيل البيبلوغرافية
الحاوية / القاعدة:Cells
المؤلفون الرئيسيون: Kai Ni, Bo Che, Rong Gu, Chunhong Wang, Yan Pan, Jingjing Li, Lei Liu, Mingzhi Luo, Linhong Deng
التنسيق: مقال
اللغة:الإنجليزية
منشور في: MDPI AG 2024-10-01
الموضوعات:
ASMC hypertrophy
contractile function
cell volume
membrane tension
Piezo1
YAP
الوصول للمادة أونلاين:https://www.mdpi.com/2073-4409/13/20/1697

الانترنت

https://www.mdpi.com/2073-4409/13/20/1697

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