From Seeds to Fibrils and Back: Fragmentation as an Overlooked Step in the Propagation of Prions and Prion-Like Proteins

Many devastating neurodegenerative diseases are driven by the misfolding of normal proteins into a pathogenic abnormal conformation. Examples of such protein misfolding diseases include Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, and prion diseases....

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Bibliographic Details

Published in:	Biomolecules
Main Authors:	Cristóbal Marrero-Winkens, Charu Sankaran, Hermann M. Schätzl
Format:	Article
Language:	English
Published:	MDPI AG 2020-09-01
Subjects:	neurodegeneration protein misfolding amyloid fragmentation disaggregation prion diseases
Online Access:	https://www.mdpi.com/2218-273X/10/9/1305