Accumulated BCAAs and BCKAs contribute to the HFD-induced deterioration of Alzheimer's disease via a dysfunctional TREM2-related reduction in microglial β-amyloid clearance

Abstract A high-fat diet (HFD) induces obesity and insulin resistance, which may exacerbate amyloid-β peptide (Aβ) pathology during Alzheimer’s disease (AD) progression. Branched-chain amino acids (BCAAs) accumulate in obese or insulin-resistant patients and animal models. However, roles of accumula...

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Bibliographic Details

Published in:	Journal of Neuroinflammation
Main Authors:	Yang Yang, Guanjin Shi, Yanyan Ge, Shanshan Huang, Ningning Cui, Le Tan, Rui Liu, Xuefeng Yang
Format:	Article
Language:	English
Published:	BMC 2024-12-01
Subjects:	Alzheimer’s disease HFD Insulin resistance BCAAs BCKAs Amyloid-β
Online Access:	https://doi.org/10.1186/s12974-024-03314-1