Enhancing T cell infiltration in glioblastoma: a review article on challenges and therapeutic strategies

This review focuses on enhancing T-cell infiltration in glioblastoma (GBM) while overcoming its immunosuppressive tumor microenvironment (TME). Key strategies include targeting myeloid-derived suppressor cells (MDSCs) to reduce immunosuppression and repolarizing tumor-associated macrophages (TAMs) f...

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Bibliographic Details

Published in:	Cancer Treatment and Research Communications
Main Authors:	Mohammad Amin Habibi, Negar Nejati, Majed Bahri Najafi, Alireza Khodadadiyan, Mohsen Dashti, Parsa Lorestani, Zahra Karimizadeh, Mahsa Ahmadpour, Amirali Kalantari, Armita Jokar-Derisi, Faezeh Maghsood, Behrouz Robat-Jazi, Elaheh Ebrahimi, Sajjad Ahmadpour, Soheil Tavakolpour
Format:	Article
Language:	English
Published:	Elsevier 2025-01-01
Subjects:	Glioblastoma Immunotherapy Tumor microenvironment Blood–brain barrier Tumor-infiltrating lymphocytes Immunosuppressive microenvironment
Online Access:	http://www.sciencedirect.com/science/article/pii/S2468294225001352