Thio-NHS esters are non-innocent protein acylating reagents
Abstract N-Hydroxysuccinimide (NHS)-ester derivatives are widely used reagents in biological chemistry and chemical biology. Their efficacy relies critically on the exclusive chemoselectivity of activated acyl over that of the imidic acyl moieties in the succinimide. Here, through systematic structu...
| Published in: | Nature Communications |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-07-01
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| Online Access: | https://doi.org/10.1038/s41467-025-60527-5 |