Adenosine metabolized from extracellular ATP ameliorates organ injury by triggering A2BR signaling

Abstract Background Trauma and a subsequent hemorrhagic shock (T/HS) result in insufficient oxygen delivery to tissues and multiple organ failure. Extracellular adenosine, which is a product of the extracellular degradation of adenosine 5’ triphosphate (ATP) by the membrane-embedded enzymes CD39 and...

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Bibliographic Details

Published in:	Respiratory Research
Main Authors:	Taha Kelestemur, Zoltán H. Németh, Pal Pacher, Jennet Beesley, Simon C. Robson, Holger K. Eltzschig, György Haskó
Format:	Article
Language:	English
Published:	BMC 2023-07-01
Subjects:	CD39 CD73 A2BR Adenosine Acute lung injury Trauma hemorrhagic shock
Online Access:	https://doi.org/10.1186/s12931-023-02486-3