CD89-mediated recruitment of macrophages via a bispecific antibody enhances anti-tumor efficacy

Since tumors are often infiltrated by macrophages, it would be advantageous to turn these types of cells into cytotoxic effector cells. Here, we have designed a novel bispecific antibody (BsAb) that targets both tumor antigen (CD20) and the FcαRI receptor (CD89). This antibody could be used to lyse...

Full description

Bibliographic Details

Published in:	OncoImmunology
Main Authors:	Bingyu Li, Lijun Xu, Chenyu Pi, Yanxin Yin, Kun Xie, Fei Tao, Renhao Li, Hua Gu, Jianmin Fang
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2018-01-01
Subjects:	bispecific antibody fcαri cd89 cd20 adcc
Online Access:	http://dx.doi.org/10.1080/2162402X.2017.1380142