MicroRNA-146a-5p-modified human umbilical cord mesenchymal stem cells enhance protection against diabetic nephropathy in rats through facilitating M2 macrophage polarization

Abstract Background Diabetic nephropathy (DN) is a severe complication of diabetes mellitus and a common cause of end-stage renal disease (ESRD). Mesenchymal stem cells (MSCs) possess potent anti-inflammatory and immunomodulatory properties, which render them an attractive therapeutic tool for tissu...

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Bibliographic Details

Published in:	Stem Cell Research & Therapy
Main Authors:	Yaqi Zhang, Xi Le, Shuo Zheng, Ke Zhang, Jing He, Mengting Liu, Chengshu Tu, Wei Rao, Hongyuan Du, Yu Ouyang, Changyong Li, Dongcheng Wu
Format:	Article
Language:	English
Published:	BMC 2022-04-01
Subjects:	Mesenchymal stem cells Diabetic nephropathy MicroRNAs Macrophage polarization
Online Access:	https://doi.org/10.1186/s13287-022-02855-7