IGF1R-phosphorylated PYCR1 facilitates ELK4 transcriptional activity and sustains tumor growth under hypoxia

Abstract The proline synthesis is importantly involved in tumor growth under hypoxia, while the underlying mechanism remains to be further investigated. Here we show that pyrroline-5-carpoxylate reductase-1 (PYCR1), displaying a constant nuclear localization, is phosphorylated by nuclear IGF1R at Ty...

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Bibliographic Details

Published in:	Nature Communications
Main Authors:	Ke Zheng, Nannan Sha, Guofang Hou, Zhuyun Leng, Qin Zhao, Li Zhang, Lingnan He, Meidong Xu, Yuhui Jiang, Tao Chen
Format:	Article
Language:	English
Published:	Nature Portfolio 2023-09-01
Online Access:	https://doi.org/10.1038/s41467-023-41658-z