EGF Activates Autocrine TGFα to Induce Prolonged EGF Receptor Signaling and Hepatocyte Proliferation

Background/Aims: EGF receptor is a main participant in the regulation of liver regeneration. In primary hepatocyte cultures, EGF or TGFα binding to EGF receptor activates Erk1/2 and PI3K pathways, induces cyclin D1 and thus initiates DNA synthesis. We have explored mechanisms by which prolonged EGF...

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Bibliographic Details

Published in:	Cellular Physiology and Biochemistry
Main Authors:	ShuZheng Liu, Lene Wierød, Ellen Skarpen, Helga Grøsvik, GuangCai Duan, Henrik S. Huitfeldt
Format:	Article
Language:	English
Published:	Cell Physiol Biochem Press GmbH & Co KG 2013-08-01
Subjects:	EGF receptor Autocrine TGFα Sustained Erk1/2 activation Cyclin D1 DNA synthesis Primary hepatocytes
Online Access:	http://www.karger.com/Article/FullText/354454