Tadalafil increases the antitumor activity of 5-FU through inhibiting PRMT5-mediated glycolysis and cell proliferation in colorectal cancer

Abstract Background Protein arginine methyltransferase 5 (PRMT5) is upregulated in multiple tumors and plays a pivotal role in cancer cell proliferation. However, the role of PRMT5 in colorectal cancer remains poorly understood. Methods We detected the expression level of PRMT5 and glycolytic enzyme...

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出版年:	Cancer & Metabolism
主要な著者:	Yao Shen, Pan Zhao, Kewei Dong, Jiajia Wang, Huichen Li, Mengyang Li, Ruikai Li, Suning Chen, Yuxia Shen, Zhiyu Liu, Mianjiao Xie, Peng Shen, Jian Zhang
フォーマット:	論文
言語:	英語
出版事項:	BMC 2022-12-01
主題:	Colorectal cancer PRMT5 Tadalafil 5-FU
オンライン･アクセス:	https://doi.org/10.1186/s40170-022-00299-4