Free amino acids accelerate the time-dependent inactivation of rat liver nucleotide pyrophosphatase/phosphodiesterase Enpp3 elicited by EDTA

Abstract Nucleotide-pyrophosphatases/phosphodiesterases (NPP/PDE) are membrane or secreted Zn2+-metallohydrolases of nucleoside-5´-monophosphate derivatives. They hydrolyze, for instance, ATP and 4-nitrophenyl-dTMP, and belong to the ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family th...

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Bibliographic Details

Published in:	Amino Acids
Main Authors:	Ana Romero, Guadalupe Cumplido-Laso, Ascensión Fernández, Javier Moreno, José Canales, Rui Ferreira, Juan López-Gómez, João Meireles Ribeiro, María Jesús Costas, José Carlos Cameselle
Format:	Article
Language:	English
Published:	Springer 2024-12-01
Subjects:	Nucleotide pyrophosphatase Phosphodiesterase Conformational change Free amino acid Rat Enpp3 ENPP family
Online Access:	https://doi.org/10.1007/s00726-024-03431-4