Human-Derived Cortical Neurospheroids Coupled to Passive, High-Density and 3D MEAs: A Valid Platform for Functional Tests

With the advent of human-induced pluripotent stem cells (hiPSCs) and differentiation protocols, methods to create in-vitro human-derived neuronal networks have been proposed. Although monolayer cultures represent a valid model, adding three-dimensionality (3D) would make them more representative of...

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Bibliographic Details

Published in:	Bioengineering
Main Authors:	Lorenzo Muzzi, Donatella Di Lisa, Matteo Falappa, Sara Pepe, Alessandro Maccione, Laura Pastorino, Sergio Martinoia, Monica Frega
Format:	Article
Language:	English
Published:	MDPI AG 2023-04-01
Subjects:	microelectrode arrays electrophysiology 3D neuronal network neurospheroids brain-on-a-chip rapid differentiation
Online Access:	https://www.mdpi.com/2306-5354/10/4/449