Attenuation of Nicotine Effects on A549 Lung Cancer Cells by Synthetic α7 nAChR Antagonists APS7-2 and APS8-2

Nicotine binds to nicotinic acetylcholine receptors (nAChRs) that are overexpressed in different cancer cells, promoting tumor growth and resistance to chemotherapy. In this study, we aimed to investigate the potential of APS7-2 and APS8-2, synthetic analogs of a marine sponge toxin, to inhibit nico...

Full description

Bibliographic Details

Published in:	Marine Drugs
Main Authors:	Ahmad Joukhan, Veno Kononenko, Tadeja Bele, Marija Sollner Dolenc, Steve Peigneur, Ernesto Lopes Pinheiro-Junior, Jan Tytgat, Tom Turk, Igor Križaj, Damjana Drobne
Format:	Article
Language:	English
Published:	MDPI AG 2024-03-01
Subjects:	marine toxin nicotinic acetylcholine receptor nAChR antagonist APS7-2 APS8-2
Online Access:	https://www.mdpi.com/1660-3397/22/4/147