Paxlovid accelerates cartilage degeneration and senescence through activating endoplasmic reticulum stress and interfering redox homeostasis

Abstract Background The COVID-19 pandemic has become a huge threat to human health, infecting millions of people worldwide and causing enormous economic losses. Many novel small molecule drugs have been developed to treat patients with COVID-19, including Paxlovid, which block the synthesis of virus...

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Bibliographic Details

Published in:	Journal of Translational Medicine
Main Authors:	Keyu Kong, Yongyun Chang, Hua Qiao, Chen Zhao, Xuzhuo Chen, Kewei Rong, Pu Zhang, Minghao Jin, Jingwei Zhang, Huiwu Li, Zanjing Zhai
Format:	Article
Language:	English
Published:	BMC 2022-11-01
Subjects:	Paxlovid COVID-19 Osteoarthritis Chondrocytes degeneration Senescence
Online Access:	https://doi.org/10.1186/s12967-022-03770-4