Protective effects of NAMPT or MAPK inhibitors and NaR on Wallerian degeneration of mammalian axons

Wallerian degeneration (WD) is a conserved axonal self-destruction program implicated in several neurological diseases. WD is driven by the degradation of the NAD+ synthesizing enzyme NMNAT2, the buildup of its substrate NMN, and the activation of the NAD+ degrading SARM1, eventually leading to axon...

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Bibliographic Details

Published in:	Neurobiology of Disease
Main Authors:	Athanasios S. Alexandris, Jiwon Ryu, Labchan Rajbhandari, Robert Harlan, James McKenney, Yiqing Wang, Susan Aja, David Graham, Arun Venkatesan, Vassilis E. Koliatsos
Format:	Article
Language:	English
Published:	Elsevier 2022-09-01
Subjects:	NAD+ Neurodegeneration Niacin SARM1 NMNAT2 Neuropathy
Online Access:	http://www.sciencedirect.com/science/article/pii/S0969996122002005