Toxic effect and inability of L-homoserine to be a nitrogen source for growth of Escherichia coli resolved by a combination of in vivo evolution engineering and omics analyses

L-homoserine is a pivotal intermediate in the carbon and nitrogen metabolism of E. coli. However, this non-canonical amino acid cannot be used as a nitrogen source for growth. Furthermore, growth of this bacterium in a synthetic media is potently inhibited by L-homoserine. To understand this dual ef...

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書誌詳細

出版年:	Frontiers in Microbiology
主要な著者:	Ceren Alkim, Daniele Farias, Julie Fredonnet, Helene Serrano-Bataille, Pauline Herviou, Marc Picot, Nawel Slama, Sebastien Dejean, Nicolas Morin, Brice Enjalbert, Jean M. François
フォーマット:	論文
言語:	英語
出版事項:	Frontiers Media S.A. 2022-12-01
主題:	Escherichia coli microbial physiology L-homoserine genetic regulation transcriptomics evolutionary engineering
オンライン･アクセス:	https://www.frontiersin.org/articles/10.3389/fmicb.2022.1051425/full