IRF4 is required for migration of CD4+ T cells to the intestine but not for Th2 and Th17 cell maintenance

The transcription factor Interferon Regulatory Factor 4 (IRF4) is central in control of T cell activation and differentiation. Deficiency of IRF4 results in severe immune deficiency and affects maturation and function of most if not all T cell subsets. Here we use mouse infection models for Citrobac...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Constantin Schmidt, Aenne Harberts, Daniel Reimers, Tabea Bertram, Leonie Caroline Voß, Joanna Schmid, Niels Christian Lory, Michael Spohn, Friedrich Koch-Nolte, Samuel Huber, Friederike Raczkowski, Minka Breloer, Hans-Willi Mittrücker
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-07-01
Subjects:	Interferon Regulatory Factor 4 Th2 cells Th17 cells Citrobacter rodentium Strongyloides ratti infection
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1182502/full