Sex- and age-related differences in the inflammatory properties of cardiac fibroblasts: impact on the cardiosplenic axis and cardiac fibrosis

BackgroundAge and sex are prominent risk factors for heart failure and determinants of structural and functional changes of the heart. Cardiac fibroblasts (cFB) are beyond their task as extracellular matrix-producing cells further recognized as inflammation-supporting cells. The present study aimed...

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Bibliographic Details

Published in:	Frontiers in Cardiovascular Medicine
Main Authors:	Kathleen Pappritz, Sarah-Lena Puhl, Isabel Matz, Erik Brauer, Yi Xuan Shia, Muhammad El-Shafeey, Suzanne E. Koch, Kapka Miteva, Christin Mucha, Georg N. Duda, Ansgar Petersen, Sabine Steffens, Carsten Tschöpe, Sophie Van Linthout
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-11-01
Subjects:	aging sex cardiac fibroblasts cardiosplenic axis monocytes fibrosis
Online Access:	https://www.frontiersin.org/articles/10.3389/fcvm.2023.1117419/full