The Dipeptide Monoester Prodrugs of Floxuridine and Gemcitabine—Feasibility of Orally Administrable Nucleoside Analogs

Dipeptide monoester prodrugs of floxuridine and gemcitabine were synthesized. Their chemical stability in buffers, enzymatic stability in cell homogenates, permeability in mouse intestinal membrane along with drug concentration in mouse plasma, and anti-proliferative activity in cancer cells were d...

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書誌詳細

出版年:	Pharmaceuticals
主要な著者:	Yasuhiro Tsume, Blanca Borras Bermejo, Gordon L. Amidon
フォーマット:	論文
言語:	英語
出版事項:	MDPI AG 2014-01-01
主題:	gemcitabine prodrug floxuridine prodrug mouse in situ perfusion pancreatic tumor cells dipeptide
オンライン･アクセス:	http://www.mdpi.com/1424-8247/7/2/169