Effects of TP53 Mutations and miRs on Immune Responses in the Tumor Microenvironment Important in Pancreatic Cancer Progression

Approximately 90% of pancreatic cancers are pancreatic ductal adenocarcinomas (PDAC). PDAC is the fourth leading cause of cancer death world-wide. Therapies for PDAC are largely ineffective due to the dense desmoplastic tumor microenvironment which prevents chemotherapeutic drugs and small molecule...

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Bibliographic Details

Published in:	Cells
Main Authors:	James A. McCubrey, Li V. Yang, Stephen L. Abrams, Linda S. Steelman, Matilde Y. Follo, Lucio Cocco, Stefano Ratti, Alberto M. Martelli, Giuseppa Augello, Melchiorre Cervello
Format:	Article
Language:	English
Published:	MDPI AG 2022-07-01
Subjects:	TP53 KRas PDAC immunotherapy miRs ncRNAs
Online Access:	https://www.mdpi.com/2073-4409/11/14/2155