Impaired antigen-specific B-cell responses after Influenza vaccination in kidney transplant recipients receiving co-stimulation blockade with Belatacept

Emerging data suggest that costimulation blockade with belatacept effectively controls humoral alloimmune responses. However, whether this effect may be deleterious for protective anti-infectious immunity remains poorly understood. We performed a mechanistic exploratory study in 23 kidney transplant...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Vincent Pernin, Maria Meneghini, Alba Torija, Thomas Jouve, Arnaud Del Bello, Iván Sanz-Muñoz, Jose Maria Eiros, Laura Donadeu, Carol Polo, Francisco Morandeira, Sergio Navarro, Cristina Masuet, Alexandre Favà, Moglie LeQuintrec, Nassim Kamar, Elena Crespo, Oriol Bestard
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-07-01
Subjects:	kidney transplantation co-stimulation blockade memory B cells influenza vaccination calcineurin inhibitors T follicular helper (Tfh) cell
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.918887/full