An Untargeted Lipidomic Analysis Reveals Depletion of Several Phospholipid Classes in Patients with Familial Hypercholesterolemia on Treatment with Evolocumab

Rationale: Familial hypercholesterolemia (FH) is caused by mutations in genes involved in low-density lipoprotein cholesterol (LDL-C) metabolism, including those for pro-protein convertase subtilisin/kexin type 9 (PCSK-9). The effect of PCSK-9 inhibition on the plasma lipidome has been poorly explor...

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Bibliographic Details
Published in:Biomedicines
Main Authors: Andrea Anesi, Alessandro Di Minno, Ilenia Calcaterra, Viviana Cavalca, Maria Tripaldella, Benedetta Porro, Matteo Nicola Dario Di Minno
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Subjects:
PCSK-9
untargeted lipidomics
familial hypercholesterolemia
Online Access:https://www.mdpi.com/2227-9059/9/12/1941

Internet

https://www.mdpi.com/2227-9059/9/12/1941

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