NRF2 Mediates Therapeutic Resistance to Chemoradiation in Colorectal Cancer through a Metabolic Switch

Radiation resistance is a significant clinical problem in rectal cancer treatment, the mechanisms of which are poorly understood. NRF2 signalling is known to contribute to chemo/radioresistance in some cancers, but its role in therapeutic resistance in colorectal cancer (CRC) is unexplored. Using si...

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Bibliographic Details

Published in:	Antioxidants
Main Authors:	Séan M. O’Cathail, Chieh-Hsi Wu, Rachael Thomas, Maria A. Hawkins, Tim S. Maughan, Annabelle Lewis
Format:	Article
Language:	English
Published:	MDPI AG 2021-08-01
Subjects:	NRF2 radiation metabolism therapeutic resistance
Online Access:	https://www.mdpi.com/2076-3921/10/9/1380