Ruscogenin Alleviates Myocardial Ischemia-Induced Ferroptosis through the Activation of BCAT1/BCAT2

Ruscogenin (RUS), a natural steroidal sapogenin, exerts various biological activities. However, its effectiveness for preventing myocardial ischemia (MI) and its molecular mechanisms need further clarification. The model of MI mice and oxygen-glucose deprivation-induced cardiomyocytes injury was per...

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Bibliographic Details

Published in:	Antioxidants
Main Authors:	Fei Fu, Qiong Lai, Jingui Hu, Lu Zhang, Xiaozhou Zhu, Junping Kou, Boyang Yu, Fang Li
Format:	Article
Language:	English
Published:	MDPI AG 2022-03-01
Subjects:	myocardial ischemia ferroptosis ruscogenin metabolomics BCAT1/BCAT2 Keap1/Nrf2/HO-1 pathway
Online Access:	https://www.mdpi.com/2076-3921/11/3/583