BRD4 facilitates osteogenic differentiation of human bone marrow mesenchymal stem cells through WNT4/NF-κB pathway

Abstract Background Human bone marrow mesenchymal stem cells (hBMSCs) are a major source of osteoblast precursor cells and are directly involved in osteoporosis (OP) progression. Bromodomain-containing protein 4 (BRD4) is an important regulator for osteogenic differentiation. Therefore, its role and...

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Bibliographic Details
Published in:Journal of Orthopaedic Surgery and Research
Main Authors: Tao Ning, Huihui Guo, Mingming Ma, Zhengang Zha
Format: Article
Language:English
Published: BMC 2023-11-01
Subjects:
Osteoporosis
hBMSCS
BRD4
WNT4
NF-κB
Glycolysis
Online Access:https://doi.org/10.1186/s13018-023-04335-x

Internet

https://doi.org/10.1186/s13018-023-04335-x

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