Mechanisms of the TGF-β1/Smad3-signaling pathway in gender differences in alcoholic liver fibrosis

Abstract The TGF-β1/Smad3-signaling pathway and gender differences were investigated in alcoholic liver fibrosis. Mice were divided into female normal, female model, male normal, and male model groups. Liver injury and fibrosis were assessed using histopathology and serology. Western blotting was pe...

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Bibliographic Details

Published in:	Journal of Physiological Sciences
Main Authors:	Xiaomin Hong, Sanqiang Li, Renli Luo, Mengli Yang, Junfei Wu, Shuning Chen, Siyu Zhu
Format:	Article
Language:	English
Published:	Elsevier 2024-02-01
Subjects:	Alcoholic liver fibrosis Gender differences Estradiol Testosterone TGF-β1/Smad3-signaling pathway
Online Access:	https://doi.org/10.1186/s12576-024-00901-y