Revealing the atomic and electronic mechanism of human manganese superoxide dismutase product inhibition

Abstract Human manganese superoxide dismutase (MnSOD) is a crucial oxidoreductase that maintains the vitality of mitochondria by converting superoxide (O2 ●−) to molecular oxygen (O2) and hydrogen peroxide (H2O2) with proton-coupled electron transfers (PCETs). Human MnSOD has evolved to be highly pr...

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Bibliographic Details

Published in:	Nature Communications
Main Authors:	Jahaun Azadmanesh, Katelyn Slobodnik, Lucas R. Struble, William E. Lutz, Leighton Coates, Kevin L. Weiss, Dean A. A. Myles, Thomas Kroll, Gloria E. O. Borgstahl
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-07-01
Online Access:	https://doi.org/10.1038/s41467-024-50260-w