Drug discovery with an RBM20 dependent titin splice reporter identifies cardenolides as lead structures to improve cardiac filling.

Diastolic dysfunction is increasingly prevalent in our ageing society and an important contributor to heart failure. The giant protein titin could serve as a therapeutic target, as its elastic properties are a main determinant of cardiac filling in diastole. This study aimed to develop a high throug...

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Bibliographic Details

Published in:	PLoS ONE
Main Authors:	Martin Liss, Michael H Radke, Jamina Eckhard, Martin Neuenschwander, Vita Dauksaite, Jens-Peter von Kries, Michael Gotthardt
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2018-01-01
Online Access:	https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0198492&type=printable