TRAIL-resistant glioma cells resist Withania somnifera mediated apoptosis via USP5 upregulation

Abstract The tumor necrosis factor related apoptosis inducing ligand (TRAIL) shows a potential therapeutic by inducing apoptosis in glioma cells and sparing normal cells, but TRAIL resistance and chemotherapeutic resistance still prevails in glioma and hinder its apoptotic effect. To address TRAIL r...

Full description

Bibliographic Details
Published in:Scientific Reports
Main Authors: Sachin Bhardwaj, Ajay Kumar Yadav
Format: Article
Language:English
Published: Nature Portfolio 2025-10-01
Subjects:
Withania somnifera
USP5
TRAIL ligand
DR5
EGFR
SMAC
Online Access:https://doi.org/10.1038/s41598-025-00917-3

Internet

https://doi.org/10.1038/s41598-025-00917-3

Similar Items