Vaccine-induced, but not natural immunity, against the Streptococcal inhibitor of complement protects against invasive disease

Abstract Highly pathogenic emm1 Streptococcus pyogenes strains secrete the multidomain Streptococcal inhibitor of complement (SIC) that binds and inactivates components of the innate immune response. We aimed to determine if naturally occurring or vaccine-induced antibodies to SIC are protective aga...

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Bibliographic Details

Published in:	npj Vaccines
Main Authors:	Lionel K. K. Tan, Mark Reglinski, Daryl Teo, Nada Reza, Lucy E. M. Lamb, Vaitehi Nageshwaran, Claire E. Turner, Mats Wikstrom, Inga-Maria Frick, Lars Bjorck, Shiranee Sriskandan
Format:	Article
Language:	English
Published:	Nature Portfolio 2021-04-01
Online Access:	https://doi.org/10.1038/s41541-021-00326-3