The Helminth Parasite Heligmosomoides polygyrus Attenuates EAE in an IL-4Rα-Dependent Manner

Helminth parasites are effective in biasing Th2 immunity and inducing regulatory pathways that minimize excessive inflammation within their hosts, thus allowing chronic infection to occur whilst also suppressing bystander atopic or autoimmune diseases. Multiple sclerosis (MS) is a severe autoimmune...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Madeleine P. J. White, Chris J. C. Johnston, John R. Grainger, Joanne E. Konkel, Richard A. O'Connor, Stephen M. Anderton, Rick M. Maizels
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2020-09-01
Subjects:	autoimmunity intestinal nematode multiple sclerosis (MS) Th2 (type-2) immune responses cytokine
Online Access:	https://www.frontiersin.org/article/10.3389/fimmu.2020.01830/full