Integrin-based diffusion barrier separates membrane domains enabling the formation of microbiostatic frustrated phagosomes

Candida albicans hyphae can reach enormous lengths, precluding their internalization by phagocytes. Nevertheless, macrophages engulf a portion of the hypha, generating incompletely sealed tubular phagosomes. These frustrated phagosomes are stabilized by a thick cuff of F-actin that polymerizes in re...

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Bibliographic Details

Published in:	eLife
Main Authors:	Michelle E Maxson, Xenia Naj, Teresa R O'Meara, Jonathan D Plumb, Leah E Cowen, Sergio Grinstein
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2018-03-01
Subjects:	macrophage Candida albicans integrins phagocytosis
Online Access:	https://elifesciences.org/articles/34798