Immunogenicity and preclinical efficacy characterization of ShecVax, a combined vaccine against Shigella and enterotoxigenic Escherichia coli

ABSTRACT No licensed vaccines are available for the largely antibiotic-resistant Shigella or enterotoxigenic Escherichia coli (ETEC), the two most common bacteria causing children’s diarrhea and travelers’ diarrhea. Virulence heterogeneity is a key obstacle to developing vaccines against Shigella or...

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Bibliographic Details

Published in:	Infection and Immunity
Main Authors:	Siqi Li, Ipshita Upadhyay, Hyesuk Seo, Sai S. R. Vakamalla, Aashwina Madhwal, David A. Sack, Weiping Zhang
Format:	Article
Language:	English
Published:	American Society for Microbiology 2025-06-01
Subjects:	Shigella enterotoxigenic Escherichia coli (ETEC) combined vaccine vaccinology platform multiepitope fusion antigen (MEFA) diarrhea
Online Access:	https://journals.asm.org/doi/10.1128/iai.00004-25