A polygenic risk score model for psoriasis based on the protein interactions of psoriasis susceptibility loci

IntroductionPolygenic Risk Scores (PRS) are an emerging tool for predicting an individual’s genetic risk to a complex trait. Several methods have been proposed to construct and calculate these scores. Here, we develop a biologically driven PRS using the UK BioBank cohort through validated protein in...

Full description

Bibliographic Details

Published in:	Frontiers in Genetics
Main Authors:	Charalabos Antonatos, Fotios Koskeridis, Christiana M. Ralliou, Evangelos Evangelou, Katerina Grafanaki, Sophia Georgiou, Konstantinos K. Tsilidis, Ioanna Tzoulaki, Yiannis Vasilopoulos
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-11-01
Subjects:	psoriasis polygenic risk score protein-protein interaction genome-wide association study risk prediction
Online Access:	https://www.frontiersin.org/articles/10.3389/fgene.2024.1451679/full