Phenylpropionic acid produced by gut microbiota alleviates acetaminophen-induced hepatotoxicity

ABSTRACTThe gut microbiota affects hepatic drug metabolism. However, gut microbial factors modulating hepatic drug metabolism are largely unknown. In this study, using a mouse model of acetaminophen (APAP)-induced hepatotoxicity, we identified a gut bacterial metabolite that controls the hepatic exp...

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Bibliographic Details

Published in:	Gut Microbes
Main Authors:	Sungjoon Cho, Xiaotong Yang, Kyoung-Jae Won, Vanessa A. Leone, Eugene B. Chang, Grace Guzman, Yeonju Ko, Ok-Nam Bae, Hyunwoo Lee, Hyunyoung Jeong
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2023-12-01
Subjects:	Mouse gut microbiota metabolomics CYP2E1 acetaminophen hepatotoxicity liver injury
Online Access:	https://www.tandfonline.com/doi/10.1080/19490976.2023.2231590