Pharmacological Targeting of the NMDAR/TRPM4 Death Signaling Complex with a TwinF Interface Inhibitor Prevents Excitotoxicity-Associated Dendritic Blebbing and Organelle Damage

Focal swellings of dendrites (“dendritic blebbing”) together with structural damage of mitochondria and the endoplasmic reticulum (ER) are morphological hallmarks of glutamate neurotoxicity, also known as excitotoxicity. These pathological alterations are generally thought to be caused by the so-cal...

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Bibliographic Details

Published in:	Cells
Main Authors:	Omar A. Ramírez, Andrea Hellwig, Zihong Zhang, Hilmar Bading
Format:	Article
Language:	English
Published:	MDPI AG 2025-01-01
Subjects:	glutamate neurotoxicity TwinF interface inhibitor NMDAR/TRPM4 complex organelle damage mitochondria endoplasmic reticulum
Online Access:	https://www.mdpi.com/2073-4409/14/3/195