Cytosolic sequestration of spatacsin by Protein Kinase A and 14-3-3 proteins

Mutations in SPG11, encoding spatacsin, constitute the major cause of autosomal recessive Hereditary Spastic Paraplegia (HSP) with thinning of the corpus callosum. Previous studies showed that spatacsin orchestrates cellular traffic events through the formation of a coat-like complex and its loss of...

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الحاوية / القاعدة:	Neurobiology of Disease
المؤلفون الرئيسيون:	Susanna Cogo, James E. Tomkins, Nikoleta Vavouraki, Veronica Giusti, Federica Forcellato, Cinzia Franchin, Isabella Tessari, Giorgio Arrigoni, Laura Cendron, Claudia Manzoni, Laura Civiero, Patrick A. Lewis, Elisa Greggio
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	Elsevier 2022-11-01
الموضوعات:	Hereditary spastic paraplegia (HSP) SPG11/Spatacsin Protein-protein interactions (PPI) 14-3-3s Protein Kinase A (PKA) Intracellular trafficking
الوصول للمادة أونلاين:	http://www.sciencedirect.com/science/article/pii/S0969996122002509