Mutational signature and clonal relatedness of recurrent urothelial carcinomas with aristolochic acid

Urothelial carcinomas (UCs) are malignant tumors that arise from the lower and upper urinary tract and are characterized by multiple recurrences. Aristolochic acid (AA) is a potent nephrotoxin and human carcinogen associated with UC. East Asian populations with a high UC prevalence have an unusual g...

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Bibliographic Details

Published in:	Frontiers in Oncology
Main Authors:	Jie Zhu, Qing Ai, Qiang Cheng, Dan Shen, Zhouhuan Dong, Jie Li, Donglai Shen, Wei Wang, Xu Zhang, Hongzhao Li
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-09-01
Subjects:	urothelial carcinomas aristolochic acid mutational signature tumor microenvironment clonal relatedness
Online Access:	https://www.frontiersin.org/articles/10.3389/fonc.2022.990023/full